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Hassan Arbab

Senior Research Scientist/Engineer

Email

mharbab@apl.washington.edu

Phone

206-685-8225

Research Interests

Terahertz spectroscopy, Ultrafast photonics and femtosecond optics, Wavelet methods, Biomedical optics

Education

B.S. Electrical Engineering, Shahid Beheshti University, 2004

M.S. Electrical Engineering, University of Washington, 2008

Ph.D. (dual) Electrical Engineering and Nanotechnology, University of Washington, 2012

Publications

2000-present and while at APL-UW

Terahertz spectroscopy for the assessment of burn injuries in vivo

Arbab, M.H., D.P. Winebrenner, T.C. Dickey, A. Chen, M.B. Klein, and P.D. Mourad, "Terahertz spectroscopy for the assessment of burn injuries in vivo," J. Biomed. Opt., 18, 077004, doi:10.1117/1.JBO.18.7.077004, 2013.

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1 Jul 2013

A diagnosis criterion is proposed for noninvasive grading of burn injuries using terahertz radiation. Experimental results are presented from in vivo terahertz time-domain spectroscopy of second- and third-degree wounds, which are obtained in a 72-hour animal study. During this period, the change in the spectroscopic response of the burned tissue is studied. It is shown that terahertz waves are sensitive not only to the postburn formation of interstitial edema, but also to the density of skin structures derived from image processing analysis of histological sections. Based on these preliminary results, it is suggested that the combination of these two effects, as probed by terahertz spectroscopy of the tissue, may ultimately be used to differentiate partial-thickness burns that will naturally heal from those that will require surgical intervention.

A noninvasive terahertz assessment of 2nd and 3rd degree burn wounds

Arbab, M.H., D.P. Winebrenner, T.C. Dickey, M.B. Klein, A. Chen, and P.D. Mourad, "A noninvasive terahertz assessment of 2nd and 3rd degree burn wounds," In Proceedings, CLEO 2012: Conference on Lasers and Electro-Optics, San Jose, CA, paper CTu3B.3 (Optical Society of America, 2012).

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6 May 2012

We demonstrate the application of THz-TDS in characterizing the severity of burn injuries in a live animal model. 2nd and 3rd degree burns were studied immediately and 72 hours post-burn. A new diagnosis criterion was verified against histopathology.

Terahertz reflectometry of burn wounds in a rat model

Arbab, M.H., T.C. Dickey, D.P. Winebrenner, A. Chen, M.B. Klein, and P.D. Mourad, "Terahertz reflectometry of burn wounds in a rat model," Biomed. Opt. Express, 2, 2339-2347, doi:10.1364/BOE.2.002339, 2011.

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21 Jul 2011

We present sub-millimeter wave reflectometry of an experimental rat skin burn model obtained by the Terahertz Time-Domain Spectroscopy (THz-TDS) technique. Full thickness burns, as confirmed by histology, were created on rats (n = 4) euthanized immediately prior to the experiments. Statistical analysis shows that the burned tissue exhibits higher reflectivity compared to normal skin over a frequency range between 0.5 and 0.7 THz (p < 0.05), likely due to post-burn formation of interstitial edema. Furthermore, we demonstrate that a double Debye dielectric relaxation model can be used to explain the terahertz response of both normal and less severely burned rat skin. Finally, our data suggest that the degree of conformation between the experimental burn measurements and the model for normal skin can potentially be used to infer the extent of burn severity.

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Inventions

Methods and systems for assessing a burn injury

The present invention provides methods, software, and systems for assessing a burn injury.

Patent Number: 9,295,402

Hassan Arbab, Antao Chen, Dale Winebrenner, Trevor Dickey, Pierre Mourad, Matthew Klein

Patent

29 Mar 2016

Terahertz spectroscopy of rough surface targets

Patent Number: 9,261,456

Hassan Arbab, Antao Chen, Eric Thorsos, Dale Winebrenner

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Patent

16 Feb 2016

A method and system for analyzing noisy terahertz spectroscopy data transforms the measured time-dependent data into frequency space, for example, using a discrete Fourier transform, and then transforms the frequency spectrum into wavelet frequency space. The twice-transformed data is analyzed to identify spectroscopic features of the signal, for example, to identify a resonance frequency. The method may be used, for example, in a stand-off detector to identify particular chemicals in a target.

Method for Characterization of Superficial Wounds

Record of Invention Number: 45573

Hassan Arbab, Antao Chen, Dale Winebrenner, Trevor Dickey, Pierre Mourad, Matthew Klein

Disclosure

1 Apr 2011

More Inventions

Acoustics Air-Sea Interaction & Remote Sensing Center for Environmental & Information Systems Center for Industrial & Medical Ultrasound Electronic & Photonic Systems Ocean Engineering Ocean Physics Polar Science Center
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